Phenotypes for Rb1 Tg(Gfap-cre)2Brn MGI:3804218 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rb1^tm2Brn/Rb1^tm2Brn Tg(Gfap-cre)2Brn/0
Genetic Background	involves: 129 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (117 available)
Tg(Gfap-cre)2Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:187257 )

neoplasm

neoplasm ( J:61961 )

N	• mutants do not develop medulloblastomas

increased pituitary gland tumor incidence ( J:187257 )

increased carcinoma incidence ( J:187257 )

• large cell carcinoma

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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