Phenotypes Associated with This Genotype

Genotype
MGI:3801419

• Allelic Composition: Fas^lpr/Fas^lpr; Ifng^tm1Ts/Ifng⁺
• Genetic Background: MRL.Cg-Ifng^tm1Ts Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:123834 )

• mice become moribund and are sacrificed at 4 months mutants posttransfer of Ifng wild-type F4/80+ macrophages at 2 months while all controls remain alive

immune system

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes

increased autoantibody level ( J:123834 )

• mice develop glomerular autoantibody deposits, but do not develop glomerulonephritis

glomerulonephritis ( J:123834 )

• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months

renal/urinary system

abnormal renal glomerulus morphology ( J:123834 )

• glomeruli are hypercellular in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

• glomerular damage is more severe in mice receiving cell transfer than in control mice not receiving transfers

abnormal glomerular capillary morphology ( J:123834 )

• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

increased mesangial cell number ( J:123834 )

• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

glomerulonephritis ( J:123834 )

• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months

homeostasis/metabolism

increased blood urea nitrogen level ( J:123834 )

• BUN levels are elevated at time of death in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

cardiovascular system

abnormal glomerular capillary morphology ( J:123834 )

• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

cellular

increased mesangial cell number ( J:123834 )

• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes

hematopoietic system

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes