Analysis Tools
immune system
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• at 4 months, kidney-infiltrating macrophages are not present; deposits of glomerular immune complexes (ICs) are not observed
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, IC deposition and glomerular proliferation are similar to control mice not receiving transfers
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, kidney interstitium remains free of macrophages, T cells, or other lymphocytes (signs of kidney interstitial inflammation) at 2 months post-transfer
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, anti-DNA autoantibody production is minimal compared to Ifng-wild-type, Faslpr homozygotes; glomerular autoantibody deposits are not observed
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• macrophage accumulation is reduced compared to Faslpr homozygotes
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes
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• mice display perivascular infiltrate composed mainly of CD4+ cells
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells
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• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration
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renal/urinary system
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• mice display perivascular infiltrate composed mainly of CD4+ cells
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells
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• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, glomerular nephritis is not observed, but severe multifocal pyogranulomatous nephritis in kidneys is observed
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respiratory system
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• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration
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cellular
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• macrophage accumulation is reduced compared to Faslpr homozygotes
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes
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hematopoietic system
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• macrophage accumulation is reduced compared to Faslpr homozygotes
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes
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