Phenotypes Associated with This Genotype

Genotype
MGI:3799534

• Allelic Composition: Fas^lpr/Fas⁺; Raf1^tm1Bacc/Raf1^tm1Bacc
• Genetic Background: involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:135681 )

N • introduction of a Fas^lpr allele onto the Raf1-null background rescues the lethality shown by the homozygous Raf1-null embryos

hematopoietic system

hematopoietic system phenotype ( J:135681 )

N • introduction of a Fas^lpr allele onto the Raf1-null background rescues the anemia observed in homozygous Raf1-null embryos

abnormal erythropoiesis ( J:135681 )

• differentiation of erythroblasts is delayed, restoring differentiation to level of Raf1 heterozygotes; differentiation is slower than observed in Raf1-null cells