Phenotypes Associated with This Genotype

Genotype
MGI:3797494

• Allelic Composition: Gfap^tm1Pkny/Gfap^tm1Pkny; Vim^tm1Cba/Vim^tm1Cba
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:124385 )

N • after cortical injury, mutants show comparable cell proliferation in injured region to controls

intracranial hemorrhage ( J:124385 )

• after a cortical stab wound was made, many mutants show extensive intracranial bleeding at site of injury 3 days after wounding, in contrast to controls and single mutants which do not display such extensive bleeding

abnormal astrocyte morphology ( J:125659 )

• cells show absence of intermediate filaments relative to wild-type

• astrocytes are smaller(35%) and exhibit fewer and shorter processes than wild-type cells

gliosis ( J:123278 )

• 3 days following surgically-induced retinal detachment (RD), mutant retinas show significantly suppressed reactive gliosis in inner nuclear layer (INL) compared to wild-type after RD

astrocytosis ( J:124385 )

• many vessels in brain and spinal cord appear dilated compared to controls

decreased neuron apoptosis ( J:123278 )

• in detached retinas of mutants 3 days after surgically-induced retinal detachment (RD), few apoptotic photoreceptor cells are detected compared to detached retinas of control mice

abnormal astrocyte physiology ( J:125659 )

• astrocytes display reduction of cell motility relative to wild-type

• rate of diffusion of astrocytes is decreased

abnormal spinal cord morphology ( J:124385 )

• dorsal spinal cord shows an unusually deep indentation in mutants compared to wild-type

• scar tissue induced by incision in dorsal funiculus is less dense and contains fissures with blood, tissue fluid or debris, compared to wild-type mice 2 days or 2 weeks after surgery

vision/eye

vision/eye phenotype ( J:123278 )

N • 7 days after RD, thickness of outer nuclear layer (ONL) is unchanged, in contrast to controls after RD where a 55% reduction in ONL thickness is observed

immune system

decreased inflammatory response ( J:123278 )

• after RD, retinas of mutants exhibit suppression of monocyte infiltration compared to wild-type retinas after RD; in controls, 3 days after RD, significant numbers of monocytes are detected in outer plexiform layer (OPL), mainly attached to photoreceptor outer segments in subretinal space (SRS)

cardiovascular system

intracranial hemorrhage ( J:124385 )

• after a cortical stab wound was made, many mutants show extensive intracranial bleeding at site of injury 3 days after wounding, in contrast to controls and single mutants which do not display such extensive bleeding

increased vasodilation ( J:124385 )

• many vessels in brain and spinal cord appear dilated compared to controls

muscle

increased vasodilation ( J:124385 )

• many vessels in brain and spinal cord appear dilated compared to controls

cellular

abnormal astrocyte morphology ( J:125659 )

• cells show absence of intermediate filaments relative to wild-type

• astrocytes are smaller(35%) and exhibit fewer and shorter processes than wild-type cells

gliosis ( J:123278 )

• 3 days following surgically-induced retinal detachment (RD), mutant retinas show significantly suppressed reactive gliosis in inner nuclear layer (INL) compared to wild-type after RD

astrocytosis ( J:124385 )

• many vessels in brain and spinal cord appear dilated compared to controls

decreased neuron apoptosis ( J:123278 )

• in detached retinas of mutants 3 days after surgically-induced retinal detachment (RD), few apoptotic photoreceptor cells are detected compared to detached retinas of control mice

abnormal astrocyte physiology ( J:125659 )

• astrocytes display reduction of cell motility relative to wild-type

• rate of diffusion of astrocytes is decreased