Vim^tm1Cba
Targeted Allele Detail

Summary

• Symbol: Vim^tm1Cba
• Name: vimentin; targeted mutation 1, Charles Babinet
• MGI ID: MGI:1931877
• Synonyms: Vim-, Vim1
• Gene: Vim Location: Chr2:13579122-13587637 bp, + strand Genetic Position: Chr2, 10.04 cM, cytoband A2
• Alliance: Vim^tm1Cba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21588
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 of the Vim gene was disrupted by insertion of a LacZ neomycin resistance cassette. Northern analysis of organs from homozygous mutant animals did not detect Vim transcript. Western analysis, immunofluorescence microsopy, and immunohistochemical studies did not detect VIM protein in tissues of homozygous mutant mice. The endogenous Vim promoter controls expression of beta-galactosidase in the targeted allele. (J:21588)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Vim^tm1Cba

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vim Mutation: 37 strains or lines available

References

• Original: J:21588 Colucci-Guyon E, et al., Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell. 1994 Nov 18;79(4):679-94
• All: 59 reference(s)