About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3796508
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Ptentm2.1Ppp/Ptentm2.1Ppp
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:130950 )
N
• unlike in Pten deficient mice, B1 B cell numbers are normal in the spleen and peritoneum
abnormal class switch recombination ( J:130950 )
• defects in class switch recombination associated with Pten deficiency are partially reversed
increased marginal zone B cell number ( J:130950 )
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice

hematopoietic system
abnormal class switch recombination ( J:130950 )
• defects in class switch recombination associated with Pten deficiency are partially reversed
increased marginal zone B cell number ( J:130950 )
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory