About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3795942
Allelic
Composition		 Hdac3tm1Swh/Hdac3tm1.1Swh
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Swh mutation (0 available); any Hdac3 mutation (31 available)
Hdac3tm1Swh mutation (0 available); any Hdac3 mutation (31 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:134665 )
• impaired cell cycle progression prior to metaphase in tamoxifen treated MEFs
increased fibroblast apoptosis ( J:134665 )
• in MEFs following tamoxifen treatment
abnormal DNA repair ( J:134665 )
• several markers of DNA damage are increased in MEFs after tamoxifen treatment

homeostasis/metabolism
abnormal DNA repair ( J:134665 )
• several markers of DNA damage are increased in MEFs after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory