Analysis Tools
mortality/aging
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• all homozygous mutant mice died within 3-5 h after birth
• no embryonic lethality and at birth homozygous mice were hard to distinguish from wild-type
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homeostasis/metabolism
dehydration
(
J:134709
)
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• homozygous neonates did not feed and became progressively dehydrated prior to death within 3-5 h after birth
• about 30 % of their body weight was lost within 3 h by increased transepidermal water loss
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• skin of mutant mice remained permeable at E18.5
• the barrier function of tight junctions were not affected
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integument
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• skin of mutant mice remained permeable at E18.5
• the barrier function of tight junctions were not affected
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• the stratum corneum is more tightly packed than in wild-type
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• numerous vacuole-like structure were observed in the upper granular layers
• EM confirmed vesicular structures of variable sizes in granular layer cells
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reddish skin
(
J:134709
)
shiny skin
(
J:134709
)
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• an increased fragility of the mutant cornified envelope
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