Phenotypes for Klrk1 Tg(IghMyc)22Bri MGI:3790962 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Klrk1^tm1Dhr/Klrk1^tm1Dhr Tg(IghMyc)22Bri/?
Genetic Background	involves: C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klrk1^tm1Dhr mutation (3 available); any Klrk1 mutation (24 available)
Tg(IghMyc)22Bri mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:134509 )

• lymphomas develop significantly earlier in these mice than in mice carrying the transgene on a wild-type background

• the mean time of onset is 7 weeks earlier than in the control group with all mice have detectable tumors by 30 weeks of age

• the tumors consist of a mix pre-B and B cells lymphomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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