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Phenotypes Associated with This Genotype
Genotype
MGI:3790961
Allelic
Composition
Klrk1tm1Dhr/Klrk1tm1Dhr
Tg(TRAMP)8247Ng/?
Genetic
Background
involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klrk1tm1Dhr mutation (3 available); any Klrk1 mutation (24 available)
Tg(TRAMP)8247Ng mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls

reproductive system
• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls

endocrine/exocrine glands
• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/31/2026
MGI 6.24
The Jackson Laboratory