Phenotypes Associated with This Genotype

Genotype
MGI:3789960

• Allelic Composition: Numb^tm1.1Ynj/Numb^tm1.1Ynj
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:62712 )

• embryos can be recovered as late as E11.5; no recognizable homozygous embryos can be found at E13.5

embryo

decreased embryo size ( J:62712 )

• at E11.5, surviving embryos are one half to two thirds the size of wild-type or heterozygous embryos

open neural tube ( J:62712 )

• at E11.5 cranial neural tube of mutants is still open but closes by E9 in normal embryos

embryo tissue necrosis ( J:62712 )

• some embryos are undergoing necrosis by E9.5, while almost all show necrosis at E11.5

growth/size/body

decreased embryo size ( J:62712 )

• at E11.5, surviving embryos are one half to two thirds the size of wild-type or heterozygous embryos

nervous system

abnormal neuron differentiation ( J:62712 )

• mutant forebrains display precocious neuron production in neocortex

open neural tube ( J:62712 )

• at E11.5 cranial neural tube of mutants is still open but closes by E9 in normal embryos

abnormal forebrain development ( J:62712 )

• in most embryos forebrain remain open at E11.5

small embryonic telencephalon ( J:62712 )

• at E11.5 in mutants with closed forebrains, telencephalic vesicles are not as prominent as in normal embryos

cellular

abnormal neuron differentiation ( J:62712 )

• mutant forebrains display precocious neuron production in neocortex