Numb^tm1.1Ynj
Targeted Allele Detail

Summary

• Symbol: Numb^tm1.1Ynj
• Name: NUMB endocytic adaptor protein; targeted mutation 1.1, Yuh Nung Jan
• MGI ID: MGI:1932086
• Synonyms: m-numb(delta 5,6)
• Gene: Numb Location: Chr12:83840808-83968708 bp, - strand Genetic Position: Chr12, 38.89 cM, cytoband D3
• Alliance: Numb^tm1.1Ynj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62712
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice homozygous for the Numb^tm1Ynj allele were mated with transgenic mice which express Cre recombinase under the control of the beta-actin promoter. The presence of Cre resulted in germline deletion of sequences in exons 5 and 6 of the Numb gene that encode the middle portion of the phosphotyrosine binding domain of the protein. C terminus immunoreactivity was not detected in protein extracts from homozygous mutant 10.5 day embryos. (J:62712)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Numb Mutation: 59 strains or lines available

References

• Original: J:62712 Zhong W, et al., Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6844-9
• All: 1 reference(s)