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Phenotypes Associated with This Genotype
Genotype
MGI:3783804
Allelic
Composition		 Apoa1tm1Unc/Apoa1tm1Unc
Tg(APOA2)3Rub/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1tm1Unc mutation (1 available); any Apoa1 mutation (14 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:129136 )
• while serum cholesterol is decreased there is an increase in the ratio of unesterified to esterified cholesterol compared to in Apoa1tm1Unc homozygotes
increased circulating triglyceride level ( J:129136 )
• triglyceride levels are increased compared to in Apoa1tm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory