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Phenotypes Associated with This Genotype
Genotype
MGI:3783527
Allelic
Composition		 Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Nes-cre)1Atp/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (12 available); any Rb1 mutation (116 available)
Rbl1tm1Tyj mutation (1 available); any Rbl1 mutation (60 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:91406 )
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt die prior to weaning

vision/eye
abnormal retina apoptosis ( J:91406 )
• mice exhibit higher apoptosis levels than in wild-type and Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice
abnormal retina morphology ( J:91406 )
• at E18.5, massive retinal dysplasia is evident

cellular
abnormal retina apoptosis ( J:91406 )
• mice exhibit higher apoptosis levels than in wild-type and Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory