Phenotypes Associated with This Genotype

Genotype
MGI:3778204

• Allelic Composition: Notch2^tm3Grid/Notch2^tm3.1Grid; Pax3^tm1(cre)Joe/Pax3⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:132939 )

• there is a 50% mortality rate between birth and weaning

cardiovascular system

pulmonary artery stenosis ( J:132939 )

• pulmonary arteries of E18.5 embryos and newborns are significantly smaller

supravalvar pulmonary trunk stenosis ( J:132939 )

• the mean inner diameter of the pulmonary trunk is 1.22 mm compared to 1.56 mm for age-matched controls

aorta stenosis ( J:132939 )

• aorta diameters of all E18.5 embryos and newborns are decreased compared to wild-type mice

• the mean aortic diameter is 1.3 mm compared to 1.5 mm for age-matched controls

abnormal vascular smooth muscle morphology ( J:132939 )

• smooth muscle cell proliferation is reduced to 9% in E16.5 embryos compared to 22.5% of wild-type embryos

craniofacial

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally

growth/size/body

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally

decreased body weight ( J:132939 )

• by one week of age, mice weigh significantly less than control littermates

homeostasis/metabolism

cyanosis ( J:132939 )

• a mild cyanotic appearance is observed in neonates

muscle

abnormal vascular smooth muscle morphology ( J:132939 )

• smooth muscle cell proliferation is reduced to 9% in E16.5 embryos compared to 22.5% of wild-type embryos

skeleton

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally