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Phenotypes Associated with This Genotype
Genotype
MGI:3776070
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2a+
Nf1tm1Tyj/Nf1+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased neurofibrosarcoma incidence ( J:131914 )
• seen at lower frequencies and greater age (over 1 year) compared to mice heterozygous for Nf1tm1Tyj and homozygous for Cdkn2atm2Rdp

nervous system
increased neurofibrosarcoma incidence ( J:131914 )
• seen at lower frequencies and greater age (over 1 year) compared to mice heterozygous for Nf1tm1Tyj and homozygous for Cdkn2atm2Rdp

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory