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Phenotypes Associated with This Genotype
Genotype
MGI:3776067
Allelic
Composition		 Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:131914 )
N
• neural crest stem cells do not abnormally persist in the peripheral nervous system in adult mice
increased neurofibrosarcoma incidence ( J:131914 )
• form by 6 months of age

neoplasm
increased neurofibrosarcoma incidence ( J:131914 )
• form by 6 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory