Mouse Genome Informatics
hm
    Pde6brd1/Pde6brd1
C3H/HeJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Retinal degeneration in Pde6brd1/Pde6brd1, and Pde6brd1/Pde6brd1 Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn mouse retinas

vision/eye
N
• despite the absence of rods, mice exhibit normal photopotentiation (defined as a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure) (J:123259)
• nearly complete absence of outer nuclear layer
• entire outer retina is destroyed, however the inner retina remains intact

nervous system

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa 40; RP40 613801 J:140115