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Phenotypes Associated with This Genotype
Genotype
MGI:3772702
Allelic
Composition
Pde6brd1/Pde6brd1
Genetic
Background
C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6brd1 mutation (92 available); any Pde6b mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Retinal degeneration in Pde6brd1/Pde6brd1, and Pde6brd1/Pde6brd1 Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn mouse retinas

vision/eye
N
• despite the absence of rods, mice exhibit normal photopotentiation (defined as a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure)
• nearly complete absence of outer nuclear layer
• entire outer retina is destroyed, however the inner retina remains intact

nervous system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 40 DOID:0110375 OMIM:613801
J:140115


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory