Phenotypes Associated with This Genotype

Genotype
MGI:3769461

• Allelic Composition: Tg(Thy1-Fcer2a)2431Putt/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:20421 )

• eosinophil numbers are increased during secondary infection with Nippostrongylus brasiliensis compared to in wild-type mice

abnormal immune system physiology ( J:129296 )

decreased IgE level ( J:20421 )

• following infection with Nippostrongylus brasiliensis, IgE levels are 2- to 9-fold lower than in wild-type mice

• by day 11 of secondary infection, IgE levels are decreased 2- to 3-fold compared to in wild-type mice

• following stimulation with anti-mouse IgD, IgG1 and IgE levels only increased by 5- to 15-fold compared to 20- to 50-fold in wild-type mice

• following stimulation with hapten, IgE levels only increase 20-fold compared to 100-fold in wild-type mice

decreased IgG1 level ( J:20421 )

• following infection with Nippostrongylus brasiliensis, IgG1 levels are 1.5- to 4-fold lower than in wild-type mice

• by day 11 of secondary infection, IgG1 levels are decreased compared to in wild-type mice

• following stimulation with anti-mouse IgD, IgG1 and IgE levels only increased by 5- to 15-fold compared to 20- to 50-fold in wild-type mice

• however, stimulation with hapten elicits a normal IgG1 response

hematopoietic system

increased eosinophil cell number ( J:20421 )

• eosinophil numbers are increased during secondary infection with Nippostrongylus brasiliensis compared to in wild-type mice

decreased IgE level ( J:20421 )

• following infection with Nippostrongylus brasiliensis, IgE levels are 2- to 9-fold lower than in wild-type mice

• by day 11 of secondary infection, IgE levels are decreased 2- to 3-fold compared to in wild-type mice

• following stimulation with anti-mouse IgD, IgG1 and IgE levels only increased by 5- to 15-fold compared to 20- to 50-fold in wild-type mice

• following stimulation with hapten, IgE levels only increase 20-fold compared to 100-fold in wild-type mice

decreased IgG1 level ( J:20421 )

• following infection with Nippostrongylus brasiliensis, IgG1 levels are 1.5- to 4-fold lower than in wild-type mice

• by day 11 of secondary infection, IgG1 levels are decreased compared to in wild-type mice

• following stimulation with anti-mouse IgD, IgG1 and IgE levels only increased by 5- to 15-fold compared to 20- to 50-fold in wild-type mice

• however, stimulation with hapten elicits a normal IgG1 response