Phenotypes Associated with This Genotype

Genotype
MGI:3767613

• Allelic Composition: Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl; Tg(Tie1-cre)9Ref/?; Gt(ROSA)26Sor^tm1Sor/?
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:128498 )

• mice are present at E9.5 but dead by E12.5

embryo

abnormal vitelline vasculature morphology ( J:128498 )

• at E9.5

absent vitelline blood vessels ( J:128498 )

• mice lack networks of vessels at all stages

embryonic growth retardation ( J:128498 )

• at E9.5, mice appear delayed by 1 day

abnormal visceral yolk sac morphology ( J:128498 )

• yolk sacs possess greater numbers of vascular smooth muscle cells than in wild-type yolk sacs

growth/size/body

embryonic growth retardation ( J:128498 )

• at E9.5, mice appear delayed by 1 day

cardiovascular system

abnormal vitelline vasculature morphology ( J:128498 )

• at E9.5

absent vitelline blood vessels ( J:128498 )

• mice lack networks of vessels at all stages

pericardial effusion ( J:128498 )

• at E9.5, hearts exhibit pericardial effusion

homeostasis/metabolism

pericardial effusion ( J:128498 )

• at E9.5, hearts exhibit pericardial effusion