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Phenotypes Associated with This Genotype
Genotype
MGI:3767597
Allelic
Composition		 Fbxw7tm1Kei/Fbxw7tm1Kei
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Kei mutation (1 available); any Fbxw7 mutation (81 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:128523 )
• mice develop double positive lymphomas at increased frequency and decreased latency compared to Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice
increased T cell derived lymphoma incidence ( J:128523 )
• at 8 weeks of age 2 mice develop thymic lymphoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:128523 )
• at 8 weeks of age 2 mice develop thymic lymphoma

immune system
immune system phenotype ( J:128523 )
N
• unlike in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice, T cells do not arrest in S phase or undergo increased apoptosis
increased T cell derived lymphoma incidence ( J:128523 )
• at 8 weeks of age 2 mice develop thymic lymphoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:128523 )
• at 8 weeks of age 2 mice develop thymic lymphoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory