Phenotypes Associated with This Genotype

Genotype
MGI:3767451

• Allelic Composition: Fas^lpr/Fas^lpr; Ighm^tm1Cgn/Ighm^tm1Cgn
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested B cell differentiation ( J:119584 )

• a transitional block in early B cell development in evident in bone marrow; pre-B cells are decreased in number

decreased mature B cell number ( J:119584 )

• number of Ig-positive B cells in spleen are 10- to 20-fold lower than in wild-type or Fas^lpr mice

increased T cell number ( J:119584 )

• cell outgrowth in lymphadenopathy is dominated by Tcrb/B220+ cells

enlarged lymph nodes ( J:119584 )

• at 8-10 weeks of age, mice develop significant lymphadenopathy

abnormal humoral immune response ( J:119584 )

• mice fail to respond to T cell-dependent (OVA) or T cell-independent (dextra) antigenic stimulation and do not produce serum specific antibodies to these antigens

abnormal immunoglobulin level ( J:119584 )

• levels of IgG2a and IgA are elevated compared to wild-type mice; significant levels (up to 10-fold) of serum antibodies have the gamma light chain isotype compared to control

decreased IgM level ( J:119584 )

• levels are much lower than in controls, comparable to Igh-6 single nulls

increased autoantibody level ( J:119584 )

• mice have high titers of chromatin antibodies compared to controls and titer increased with age; anti-cardiolipin antibodies are increased in serum in 40% of double mutants

hematopoietic system

arrested B cell differentiation ( J:119584 )

• a transitional block in early B cell development in evident in bone marrow; pre-B cells are decreased in number

decreased mature B cell number ( J:119584 )

• number of Ig-positive B cells in spleen are 10- to 20-fold lower than in wild-type or Fas^lpr mice

increased T cell number ( J:119584 )

• cell outgrowth in lymphadenopathy is dominated by Tcrb/B220+ cells

abnormal immunoglobulin level ( J:119584 )

• levels of IgG2a and IgA are elevated compared to wild-type mice; significant levels (up to 10-fold) of serum antibodies have the gamma light chain isotype compared to control

decreased IgM level ( J:119584 )

• levels are much lower than in controls, comparable to Igh-6 single nulls

homeostasis/metabolism

increased urine protein level ( J:119584 )

• mice show significant proteinuria

renal/urinary system

increased urine protein level ( J:119584 )

• mice show significant proteinuria