Phenotypes Associated with This Genotype

Genotype
MGI:3766950

• Allelic Composition: Sele^tm2Alb/Sele^tm2Alb; Selp^tm1Bay/Selp^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:70682 )

• rolling is severely compromised

• rolling flux and rolling fraction are reduced relative to wild-type

increased leukocyte cell number ( J:70682 )

• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type

increased eosinophil cell number ( J:70682 )

increased neutrophil cell number ( J:70682 , J:112286 )

• circulating neutrophils are increased in mutants and this increases with age of mice (J:112286)

• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions (J:112286)

increased monocyte cell number ( J:70682 )

abnormal spleen B cell follicle morphology ( J:70682 )

• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis

decreased spleen B cell follicle number ( J:70682 )

abnormal neutrophil physiology ( J:112286 )

• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model

• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type

• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups

abnormal lymph node secondary follicle morphology ( J:70682 )

• structures aren't recognized in mutant cervical lymph nodes

abnormal lymph node germinal center morphology ( J:70682 )

• structures aren't recognized in mutant cervical lymph nodes

enlarged lymph nodes ( J:70682 )

• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice

abnormal cytokine secretion ( J:70682 )

• GM-CSF levels are elevated 6-7-fold above levels in wild-type or Sell-null mice

decreased acute inflammation ( J:112286 )

• standardized volume fraction of emigrated neutrophils in dermis of irritated ears is 0.017 +/- 0.006, compared to 0.317 in irritated ears of wild-type mice

hematopoietic system

impaired leukocyte tethering or rolling ( J:70682 )

• rolling is severely compromised

• rolling flux and rolling fraction are reduced relative to wild-type

extramedullary hematopoiesis ( J:70682 )

• mice show massive extramedullary hematopoiesis with identifiable myeloid and megakaryocytic lineages, and lesser erythroid component

increased leukocyte cell number ( J:70682 )

• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type

increased eosinophil cell number ( J:70682 )

increased neutrophil cell number ( J:70682 , J:112286 )

• circulating neutrophils are increased in mutants and this increases with age of mice (J:112286)

• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions (J:112286)

increased monocyte cell number ( J:70682 )

abnormal spleen B cell follicle morphology ( J:70682 )

• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis

decreased spleen B cell follicle number ( J:70682 )

abnormal neutrophil physiology ( J:112286 )

• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model

• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type

• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups

cardiovascular system

abnormal lung vasculature morphology ( J:70682 )

• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces

respiratory system

abnormal lung morphology ( J:70682 )

• lung tissue displays decreasing cellularity within alveolocapillary walls with severely affected interstitial areas

abnormal lung vasculature morphology ( J:70682 )

• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces

integument

spontaneous skin ulceration ( J:70682 , J:112286 )

• mice develop mucocutaneous infections or ulcerative dermatitis (J:70682)

• at 15 months, mice show large areas of ulceration on the neck (J:70682)

• mice develop spontaneous skin lesions characterized by polymorphonuclear leukocytes (J:112286)

cellular

impaired leukocyte tethering or rolling ( J:70682 )

• rolling is severely compromised

• rolling flux and rolling fraction are reduced relative to wild-type