Phenotypes Associated with This Genotype

Genotype
MGI:3766947

• Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay; Sele^tm2Alb/Sele^tm2Alb; Selp^tm1Bay/Selp^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:112286 )

• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation

increased neutrophil cell number ( J:112286 )

• circulating neutrophils are increased in mice with acute croton oil dermatitis

decreased acute inflammation ( J:112286 )

• in response to croton oil application to the ear in young mice (7-14 weeks), inflammation is significantly reduced relative to controls

hematopoietic system

impaired neutrophil chemotaxis ( J:112286 )

• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation

increased neutrophil cell number ( J:112286 )

• circulating neutrophils are increased in mice with acute croton oil dermatitis

homeostasis/metabolism

skin edema ( J:112286 )

• dermal edema is decreased by 41% within 6 hours of croton oil irritation in young mice (7-14 weeks), and partial suppression of edema in older (23-35 weeks) mice

integument

integument phenotype ( J:112286 )

N • triply deficient mice do not develop spontaneous skin lesions up to 55 weeks of age

skin edema ( J:112286 )

• dermal edema is decreased by 41% within 6 hours of croton oil irritation in young mice (7-14 weeks), and partial suppression of edema in older (23-35 weeks) mice

cellular

impaired neutrophil chemotaxis ( J:112286 )

• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation