Phenotypes Associated with This Genotype

Genotype
MGI:3765910

• Allelic Composition: F11r^{Gt(KST235)Byg}/F11r^{Gt(KST235)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:127992 )

• 40% fewer embryos than expected are born

• fewer males than expected are born

• however, mice that are born survive into adulthood

cardiovascular system

cardiovascular system phenotype ( J:127992 )

N • embryonic and retinal vasculature are normal

decreased angiogenesis ( J:127992 )

• aortic rings fail to undergo FGF2-induced sprouting

• matrigel plugs exhibit decreased FGF2-induced neovascularization