Phenotypes Associated with This Genotype

Genotype
MGI:3764845

• Allelic Composition: App^tm1Somm/App^tm1Somm
• Genetic Background: C57BL/6-App^tm1Somm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired passive avoidance behavior ( J:127367 )

• at 8 months of age mice display impaired passive avoidance retention latency

decreased grip strength ( J:127367 )

• mice exhibit reduced forelimb grip strength at 3 months (23% reduction) and 8 months (22% reduction) compared to wild-type mice

• mice exhibit decreased grip to body weight at 3 months (15% reduction) and 8 months (11% reduction) compared to wild-type mice

decreased locomotor activity ( J:127367 )

• at 3 months of age, mice exhibit decreased locomotor activity (2640+/-358 beam breaks compared to 3472+/-394 beam breaks for wild-type mice)

• however, locomotor activity is normal at 8 and 10 months of age and spontaneous alternation behavior is normal at 3 and 8 months

nervous system

abnormal excitatory postsynaptic currents ( J:276486 )

• less efficient in baclofen-induced reduction of evoked EPSC amplitude and mEPSC frequency, but not amplitude

• less pronounced resistance to baclofen-induced reduction of mEPSC frequency than in hippocampal slices from Gabbr1 homozygotes

• however, baseline mEPSC frequency and amplitude are normal

growth/size/body

decreased body weight ( J:127367 )

• body weight is reduced by 7% at 3 months of age and 12% at 8 months of age compared to wild-type mice