Gabbr1tm3Bet
Targeted Allele Detail
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| Symbol: |
Gabbr1tm3Bet |
| Name: |
gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 3, Bernhard Bettler |
| MGI ID: |
MGI:3665432 |
| Synonyms: |
1a-, GABAB(1a)-, GABAB1a-, GB1a- |
| Gene: |
Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
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| Alliance: |
Gabbr1tm3Bet page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:113340
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
BALB/c
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| Allele Type: |
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Targeted (Modified isoform(s)) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: The start codon for the B1a isoform of Gabbr1 was converted into a stop codon to prevent translation of the B1a isoform. A putative alternative start site was also mutated and a floxed neomycin cassette was inserted in the introns between exons 2a and 3a. The neomycin cassette was removed by crossing with mice expressing Cre-recombinase under the control of the cytomegalus virus promoter. Northern blot analysis confirmed absence of the B1a isoform.
(J:113340)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gabbr1 Mutation: |
74 strains or lines available
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| Original: |
J:113340 Vigot R, et al., Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 2006 May 18;50(4):589-601 |
| All: |
18 reference(s) |
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Analysis Tools
