Phenotypes Associated with This Genotype

Genotype
MGI:3761936

• Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Rmh; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

enhanced osteoblast differentiation ( J:126375 )

• in vitro osteoblast maturation is enhanced

increased trabecular bone volume ( J:126375 )

• 40% increase in trabecular bone volume due to increased bone thickness

increased trabecular bone thickness ( J:126375 )

increased bone mineralization ( J:126375 )

• the mineral apposition rate is enhanced

increased bone ossification ( J:126375 )

• bone formation rate is 2.5 fold higher than in littermate controls

cellular

enhanced osteoblast differentiation ( J:126375 )

• in vitro osteoblast maturation is enhanced