Phenotypes Associated with This Genotype

Genotype
MGI:3760792

• Allelic Composition: Kit^Whc1/Kit^Whc1
• Genetic Background: involves: C3HeB/Fe * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Germ cell phenotypes of Kit^Mhdasco1/Kit^Mhdasco1, Kit^Mhdasow3/Kit^Mhdasow3, Kit^Mhdasco5/Kit^Mhdasco5, Kit^tm1Alf/Kit^Mhdasow3 and Kit^Whc1/Kit^Whc1 mice

mortality/aging

postnatal lethality ( J:125831 )

• 50% death before 7.5 days of age

• 25% survival to weaning

growth/size/body

slow postnatal weight gain ( J:125831 )

• 50% weight reduction at 21 days after birth

pigmentation

abnormal coat/hair pigmentation ( J:125831 )

• overall pale coat color with black eyes

hematopoietic system

macrocytic anemia ( J:125831 )

• at 7.5 days of age

• severe

abnormal erythrocyte morphology ( J:125831 )

decreased erythrocyte cell number ( J:125831 )

• 3.4x10⁶/ul

decreased hematocrit ( J:125831 )

• 25.7%

increased hemoglobin content ( J:125831 )

• 8.4g/dl

increased mean corpuscular volume ( J:125831 )

• 77.3 femptoliters

liver/biliary system

hepatic steatosis ( J:125831 )

• tan or yellowish in color at 7.5 days of age due to steatosis

• modest

reproductive system

reproductive system phenotype ( J:125831 )

N • spermatogenesis appears normal

integument

abnormal coat/hair pigmentation ( J:125831 )

• overall pale coat color with black eyes