Phenotypes Associated with This Genotype

Genotype
MGI:3760623

• Allelic Composition: Cd8a^tm1Asin/Cd8a^tm1Mak
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates

abnormal T cell subpopulation ratio ( J:126026 )

• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus

hematopoietic system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates

abnormal T cell subpopulation ratio ( J:126026 )

• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus