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Phenotypes Associated with This Genotype
Genotype
MGI:3759457
Allelic
Composition
SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (47 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

mortality/aging
• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months

neoplasm
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:173443


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory