Phenotypes Associated with This Genotype

Genotype
MGI:3758050

• Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myocardial fiber mitochondrial morphology ( J:116167 )

• the mitochondrial volume fraction is reduced (35.3+/-0.3% compared to 42.8+/-2.8% in wild-type mice) in the heart

abnormal skeletal muscle fiber mitochondrial morphology ( J:116167 )

• the mitochondrial volume fraction is reduced (16.8+/-0.8% compared to 20.4+/-0.7% in wild-type mice) in soleus muscle fiber

homeostasis/metabolism

decreased circulating cholesterol level ( J:116167 )

• when fed chow or a high fat diet mice exhibit higher serum cholesterol levels compared to wild-type mice (chow, 2.20+/-0.23 mM compared to 3.34+/-0.20 mM; high fat diet, 3.45+/-0.30 mM compared to 5.37+/-0.24 mM)

decreased circulating triglyceride level ( J:116167 )

• with a 24 hours Surwit high fat diet challenge, triglyceride levels are lower than in similarly treated wild-type mice (0.35+/-0.03 mM versus 0.39+/-0.03 mM in wild-type mice)

decreased oxygen consumption ( J:116167 )

• when cold-acclimatized mice are treated with norepinephrine to oxygen consumption increases to only 60% of that observed in wild-type mice under the same conditions

• unlike in wild-type mice, thermoneutral mice treated with norepinephrine show no increase in oxygen consumption

abnormal metabolism ( J:116167 )

• at 9 week, the minimal metabolic rate at 22 degrees Celsius is increased

• at ambient temperature mice have an increased metabolic rate whereas at thermoneutrality and when cold-acclimatized mice have a lower metabolic rate relative to wild-type mice

adipose tissue

decreased gonadal fat pad weight ( J:116167 )

• the gondal fat pad in 14 week old males is smaller than in wild-type mice

abnormal white adipose tissue morphology ( J:116167 )

• the fraction of small adipocytes (less than 2000 um²) is reduced and the fraction of large adipocytes is increased relative to in wild-type mice in male gonadal white adipose tissue

decreased white adipose tissue amount ( J:116167 )

• on a chow diet, mice have less total white adipose tissue content than wild-type mice but was composed of larger adipocytes

increased white fat cell size ( J:116167 )

• white adipose tissue adipocytes are larger in male gonadal, subcutaneous and omental white adipose tissue and in female gonadal white adipose tissue

cardiovascular system

abnormal myocardial fiber mitochondrial morphology ( J:116167 )

• the mitochondrial volume fraction is reduced (35.3+/-0.3% compared to 42.8+/-2.8% in wild-type mice) in the heart

decreased heart rate ( J:116167 )

• mice exhibit a blunted increase in heart rate compared to wild-type mice when treated with 10 ng/min/g of dobutamine (beta1,alpha1-adrenergic selective agonist) and was even more evident at 40ng/min/g dobutamine

cellular

abnormal myocardial fiber mitochondrial morphology ( J:116167 )

• the mitochondrial volume fraction is reduced (35.3+/-0.3% compared to 42.8+/-2.8% in wild-type mice) in the heart

abnormal skeletal muscle fiber mitochondrial morphology ( J:116167 )

• the mitochondrial volume fraction is reduced (16.8+/-0.8% compared to 20.4+/-0.7% in wild-type mice) in soleus muscle fiber

growth/size/body

decreased body weight ( J:116167 )

• mice weigh less than wild-type mice

increased liver weight ( J:116167 )

• with a 24 hours Surwit high fat diet challenge, mice exhibit increased liver weight increases but wild-type mice do not

liver/biliary system

increased liver weight ( J:116167 )

• with a 24 hours Surwit high fat diet challenge, mice exhibit increased liver weight increases but wild-type mice do not

hepatic steatosis ( J:116167 )

• with a 24 hours Surwit high fat diet challenge, mice develop severe steatosis whereas wild-type mice do not