Phenotypes Associated with This Genotype

Genotype
MGI:3720867

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:30174 )

• 8 of 37 mice die at 8.8+/-1.7 weeks of age

reproductive system

reduced female fertility ( J:30174 )

♀

growth/size/body

decreased body weight ( J:30174 )

• at 4 weeks of age, mice weight less than their wild-type littermates

• at 5.3+/-0.3 weeks of age, 4 of 37 mice are runted and apathic

• at week 8 mice, weighed 17.3+/-1.3g compared to wild-type mice that weigh 21.8+/-1.2g

enlarged kidney ( J:30174 )

• 4 mice develop unilateral or bilateral kidney enlargement with pelvis distention and urine accumulation without fibrous adhesions in the peritoneum

digestive/alimentary system

rectal prolapse ( J:30174 )

• 7 of 37 mice develop rectal prolapse whereas no wild-type mice did at 6.4+/-0.6 weeks of age

gastric ulcer ( J:30174 )

• one mouse had fibrin deposition at the base of a large gastric ulceration with loss of the intact architecture of the overlying epithelium and infiltration of inflammatory cells

homeostasis/metabolism

abnormal blood coagulation ( J:30174 )

• 24 hours fibrin clot lysis is reduced to -2+/-1% compare to 85+/-5% in wild-type mice

liver/biliary system

liver fibrosis ( J:30174 )

• all mice have white spots composed of fibrin on their livers at 6 to 12 weeks of age

renal/urinary system

enlarged kidney ( J:30174 )

• 4 mice develop unilateral or bilateral kidney enlargement with pelvis distention and urine accumulation without fibrous adhesions in the peritoneum

respiratory system

pulmonary fibrosis ( J:30174 )

• fibrin deposits are detected in the lungs of 3 mice