Phenotypes Associated with This Genotype

Genotype
MGI:3718912

• Allelic Composition: App^tm1Cwe/App^tm1Cwe
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:123316 )

• take about twice as long to find the platform and swim greater distances in a water maze

abnormal emotion/affect behavior ( J:123316 )

decreased exploration in new environment ( J:123316 )

• decreased exploratory behavior under aversive conditions

increased thigmotaxis ( J:123316 )

• increased wall-hugging in a water maze

abnormal motor capabilities/coordination/movement ( J:123316 )

impaired swimming ( J:123316 )

• swim speed is decreased by 19% compared to controls

decreased grip strength ( J:123316 )

• grip strength deficit of 23% compared to controls

abnormal locomotor activation ( J:123316 )

• significantly increased activity levels at the beginning of the dark period and decreased activity levels at the end of the dark period compared to controls

abnormal circadian behavior ( J:123316 )

• abnormal circadian distribution of activity

nervous system

decreased brain weight ( J:123316 )

• brain wet weight is reduced by about 11% at 10 - 12 months of age

reduced long-term potentiation ( J:123316 )

• deficit in long term potentiation in mice at 9 to 12 months of age

growth/size/body

decreased body weight ( J:123316 )

• reduced by about 15% and 19% compared to wild-type in females and males, respectively at 2.4 months of age