Phenotypes Associated with This Genotype

Genotype
MGI:3716167

• Allelic Composition: Cd79a^tm3Cgn/Cd79a^tm3Cgn; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:88620 )

• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen

abnormal metallophilic macrophage morphology ( J:88620 )

• following treatment with poly(I)/poly(C), marginal metallophilic macrophages are decreased in number in areas where B cell numbers are reduced

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• following treatment with poly(I)/poly(C), marginal zone metallophilic macrophages are decreased in number in areas where B cell numbers are reduced

abnormal spleen red pulp morphology ( J:88620 )

• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen

• following treatment with poly(I)/poly(C), follicles are reduced in size

immune system

decreased B cell number ( J:88620 )

• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen

abnormal metallophilic macrophage morphology ( J:88620 )

• following treatment with poly(I)/poly(C), marginal metallophilic macrophages are decreased in number in areas where B cell numbers are reduced

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• following treatment with poly(I)/poly(C), marginal zone metallophilic macrophages are decreased in number in areas where B cell numbers are reduced

abnormal spleen red pulp morphology ( J:88620 )

• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen

• following treatment with poly(I)/poly(C), follicles are reduced in size