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Phenotypes Associated with This Genotype
Genotype
MGI:3715481
Allelic
Composition		 Gdnftm1Rosl/Gdnf+
Itga8tm1Lfr/Itga8tm1Lfr
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Rosl mutation (0 available); any Gdnf mutation (20 available)
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney morphology ( J:122519 )
• only kidney observed is highly dysplastic
absent kidney ( J:122519 )
• 95% kidney agenesis incidence; only 1 kidney is found in total in 11 animals

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory