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Phenotypes Associated with This Genotype
Genotype
MGI:3715216
Allelic
Composition		 Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (11 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (11 available)
Snai2tm2Grid mutation (1 available); any Snai2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:121243 )
• resulting from cleft palate

craniofacial
abnormal Meckel's cartilage morphology ( J:121243 )
• the rostral portion of the Meckels cartilage is missing in neonates
frontal bone foramen ( J:121243 )
• enlarged frontal foramen in neonates
short parietal bone ( J:121243 )
• nenates have shortened parietal bones
short mandible ( J:121243 )
• mandible is shorter than in wild-type
domed cranium ( J:121243 )
• in neonates
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate

skeleton
abnormal Meckel's cartilage morphology ( J:121243 )
• the rostral portion of the Meckels cartilage is missing in neonates
frontal bone foramen ( J:121243 )
• enlarged frontal foramen in neonates
short parietal bone ( J:121243 )
• nenates have shortened parietal bones
short mandible ( J:121243 )
• mandible is shorter than in wild-type
domed cranium ( J:121243 )
• in neonates

digestive/alimentary system
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate

growth/size/body
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory