Phenotypes Associated with This Genotype

Genotype
MGI:3715096

• Allelic Composition: Pdgfra^tm8Sor/Pdgfra^tm8Sor; Pdgfrb^tm1Mdt/Pdgfrb^tm1Mdt; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:122584 )

• 100% of mice die after birth

cardiovascular system

retroesophageal right subclavian artery ( J:122584 )

• in 100% of mice

persistent truncus arteriosus ( J:122584 )

• in 100% of mice

ventricular septal defect ( J:122584 )

• in 100% of mice

hematopoietic system

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

craniofacial

cleft palate ( J:122584 )

• at birth

homeostasis/metabolism

cyanosis ( J:122584 )

• at birth

immune system

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

digestive/alimentary system

cleft palate ( J:122584 )

• at birth

embryo

abnormal cardiac neural crest cell migration ( J:122584 )

• neural crest cell (NCC) migration defects occur in the conotruncus region

• NCCs fail to migrate to the thymic epithelium

cellular

abnormal cardiac neural crest cell migration ( J:122584 )

• neural crest cell (NCC) migration defects occur in the conotruncus region

• NCCs fail to migrate to the thymic epithelium

endocrine/exocrine glands

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

growth/size/body

cleft palate ( J:122584 )

• at birth