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Phenotypes Associated with This Genotype
Genotype
MGI:3714327
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(DO11.10)10Dlo/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:110446 )
N
• T cells exhibit similar levels of activation induced cell death as Rag2-, Ctla4-deficient, Tg (DO11.10)10Dlo T cells
• cells undergo tolerance induction in vivo in response to an immunizing or tolerizing stimulus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory