Phenotypes Associated with This Genotype

Genotype
MGI:3713641

• Allelic Composition: Rbpj^tm1Kyo/Rbpj^tm1Kyo
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

abnormal fetal cardiomyocyte proliferation ( J:119151 )

• decrease in cardiomyocyte proliferation at E9.5

muscle

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

abnormal fetal cardiomyocyte proliferation ( J:119151 )

• decrease in cardiomyocyte proliferation at E9.5

immune system

abnormal humoral immune response ( J:123631 )

• following exposure to Schistosoma mansoni soluble egg antigen, the T helper 2-dependent antibody production is abrogated

decreased interleukin-4 secretion ( J:123631 )

• following exposure to Schistosoma mansoni soluble egg antigen, IL-4 secretion is abolished

abnormal response to infection ( J:123631 )

• following exposure to Schistosoma mansoni soluble egg antigen, the T helper 2-dependent antibody production and IL-4 secretion are abrogated

cellular

abnormal fetal cardiomyocyte proliferation ( J:119151 )

• decrease in cardiomyocyte proliferation at E9.5