Phenotypes Associated with This Genotype

Genotype
MGI:3710771

• Allelic Composition: Rbm15^tm1Dgg/Rbm15^tm1.1Dgg; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells, indicating a block in pre/pre-B differentiation

increased megakaryocyte cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, 2 fold increase in megakaryocytes is observed

decreased B cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, the total WBC count gradually decreases over a 6 week period resulting from a striking decline in peripheral B lymphocytes

decreased pre-B cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells

increased hematopoietic stem cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an increase in the hematopoietic stem cells and shift in progenitor fate toward granulocyte differentiation is observed

increased spleen red pulp amount ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an expansion of the splenic red pulp is observed

immune system

abnormal B cell differentiation ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells, indicating a block in pre/pre-B differentiation

decreased B cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, the total WBC count gradually decreases over a 6 week period resulting from a striking decline in peripheral B lymphocytes

decreased pre-B cell number ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells

increased spleen red pulp amount ( J:120321 )

• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an expansion of the splenic red pulp is observed