Phenotypes Associated with This Genotype

Genotype
MGI:3706809

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl}/Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112660 )

• wheni injected with poly(I:C) to induce cre expression, mutants become moribund and die within 2-3 weeks

immune system

thymus hypoplasia ( J:112660 )

• after cre induction, mutants have ~25% of control cell numbers in thymus

arrested T cell differentiation ( J:112660 )

• a block at the DN1-DN2 transition is found

impaired myelopoiesis ( J:112660 )

• myeloid cells are almost totally absent in induced mutants

decreased leukocyte cell number ( J:112660 )

• induced mutants have fewer leukocytes

decreased double-negative T cell number ( J:112660 )

• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells

decreased granulocyte number ( J:112660 )

• after cre induction, mice show a loss of granulocytic cells

hematopoietic system

thymus hypoplasia ( J:112660 )

• after cre induction, mutants have ~25% of control cell numbers in thymus

arrested T cell differentiation ( J:112660 )

• a block at the DN1-DN2 transition is found

impaired myelopoiesis ( J:112660 )

• myeloid cells are almost totally absent in induced mutants

anemia ( J:112660 )

• after cre induction, mice develop severe anemia

abnormal bone marrow cell number ( J:112660 )

• after cre induction, mutants have ~25% of control bone marrow cell numbers

abnormal proerythroblast morphology ( J:112660 )

• bone marrow shows abnormal presence of immature erythroid cells in induced mutants

decreased erythrocyte cell number ( J:112660 )

• peripheral blood from induced mutants is pale and has reduced red blood cell counts

decreased hemoglobin content ( J:112660 )

• hemoglobin concentration in peripheral blood of induced mutants is reduced

thrombocytopenia ( J:112660 )

• platelet count in induced mutants is reduced

decreased leukocyte cell number ( J:112660 )

• induced mutants have fewer leukocytes

decreased double-negative T cell number ( J:112660 )

• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells

decreased granulocyte number ( J:112660 )

• after cre induction, mice show a loss of granulocytic cells

endocrine/exocrine glands

thymus hypoplasia ( J:112660 )

• after cre induction, mutants have ~25% of control cell numbers in thymus