Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1 Claus Nerlov
• MGI ID: MGI:3664628
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112660
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CTNNB1)Nerl} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CTNNB1 (1499)

  Ctnnb1

  (MGI:88276)

• Mutation details: A cDNA encoding a Myc-tagged stable form of human CTNNB1 was inserted into the locus downstream of a floxed neo cassette using RecE-RecT recombination. Cre mediated removal of the neo allows expression of the inserted gene. (J:112660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:112660 Kirstetter P, et al., Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol. 2006 Oct;7(10):1048-56
• All: 3 reference(s)