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Phenotypes Associated with This Genotype
Genotype
MGI:3703883
Allelic
Composition		 Smad2tm1.1Epb/Smad2tm1.1Epb
Smad3tm1Cxd/Smad3tm1Cxd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.1Epb mutation (1 available); any Smad2 mutation (50 available)
Smad3tm1Cxd mutation (0 available); any Smad3 mutation (18 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:119642 )
N
• mice exhibit normal postnatal liver and body growth and function

cellular
abnormal cell morphology ( J:119642 )
• only a few hepatocytes attach with atypical morphology after seeding
abnormal cell physiology ( J:119642 )
• isolated primary hepatocytes show decreased viability immediately upon isolation, prior to plating (<70% viable cells) compared to controls or other mutant genotypes

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:119642 )
• injection of CCL4 to the liver induces a greater degree of liver injury in mice compared to control or individual single knockout mice; advanced bridging central injury is induced in livers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory