Phenotypes Associated with This Genotype

Genotype
MGI:3701504

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112659 )

• mice die within 14-18 days of final injection of polyI:polyC used to induce transgene expression and subsequent Ctnnb1 deletion; no treated controls die

skeleton

abnormal trabecular bone morphology ( J:112659 )

• some induced mice show disrupted bone architecture with enhanced trabecular bone structures

neoplasm

increased hepatoblastoma incidence ( J:112659 )

• some induced mutants display hepatoblastoma

integument

skin fibrosis ( J:112659 )

• some induced mice display skin fibrosis

liver/biliary system

increased hepatoblastoma incidence ( J:112659 )

• some induced mutants display hepatoblastoma