Phenotypes Associated with This Genotype

Genotype
MGI:3695429

• Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp; Kras^tm4Tyj/Kras⁺; Smad4^tm1Rdp/Smad4^tm1Rdp; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:116130 )

• average tumor-free survival is 7.4 weeks

neoplasm

increased tumor incidence ( J:116130 )

• 3 of 10 mice develop intraductal papillary mucinous neoplasms

• tumor fibrosis is increased compared to mice wild-type for Smad4

increased stomach tumor incidence ( J:116130 )

• 5 of 10 mice develop gastric cancer

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 9 of 10 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

digestive/alimentary system

increased stomach tumor incidence ( J:116130 )

• 5 of 10 mice develop gastric cancer

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 9 of 10 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4