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Phenotypes Associated with This Genotype
Genotype
MGI:3695426
Allelic
Composition		 Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (59 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (46 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:116130 )
• average tumor-free survival is 12.6 weeks

neoplasm
increased tumor incidence ( J:116130 )
• 4 of 12 mice develop intraductal papillary mucinous neoplasms
• tumor fibrosis is increased compared to mice wild-type for Smad4
increased stomach tumor incidence ( J:116130 )
• 8 of 12 mice develop gastric cancer
increased pancreatic ductal adenocarcinoma incidence ( J:116130 )
• 4 of 12 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

digestive/alimentary system
increased stomach tumor incidence ( J:116130 )
• 8 of 12 mice develop gastric cancer

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:116130 )
• 4 of 12 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory