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Phenotypes Associated with This Genotype
Genotype
MGI:3695422
Allelic
Composition		 Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (43 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased stomach tumor incidence ( J:116130 )
• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology

mortality/aging
decreased tumor-free survival time ( J:116130 )
• mice die between 8 and 24 weeks of age
• average tumor-free survival is 13.1 weeks

endocrine/exocrine glands
pancreas cyst ( J:116130 )
• seen in all mice

growth/size/body
pancreas cyst ( J:116130 )
• seen in all mice

neoplasm
increased tumor incidence ( J:116130 )
• 5 of 8 mice develop intraductal papillary mucinous neoplasms
increased stomach tumor incidence ( J:116130 )
• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory