Phenotypes Associated with This Genotype

Genotype
MGI:3695422

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Smad4^tm1Rdp/Smad4^tm1Rdp; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased stomach tumor incidence ( J:116130 )

• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology

mortality/aging

decreased tumor-free survival time ( J:116130 )

• mice die between 8 and 24 weeks of age

• average tumor-free survival is 13.1 weeks

endocrine/exocrine glands

pancreas cyst ( J:116130 )

• seen in all mice

growth/size/body

pancreas cyst ( J:116130 )

• seen in all mice

neoplasm

increased tumor incidence ( J:116130 )

• 5 of 8 mice develop intraductal papillary mucinous neoplasms

increased stomach tumor incidence ( J:116130 )

• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology