Phenotypes for Cdkn2a Trp53 MGI:3694644 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (5 available); any Cdkn2a mutation (59 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Persistent hyperplastic primary vitreous (PHPV) in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice is p53 independent

vision/eye

abnormal eye morphology ( J:75215 )

• exhibit a similar eye phenotype as seen in single Cdkn2a homozygotes that is not altered by the absence of Trp53

abnormal lens capsule morphology ( J:75215 )

• lens capsule destruction to a similar extent as in single Cdkn2a homozygotes

persistent hyperplastic primary vitreous ( J:75215 )

• failure of hyaloid vascular regression similar to that seen in single Cdkn2a homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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